Is poor sleep a dementia risk factor?

Presenter: A/Prof Matthew Pase

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About the presentation

Sleep disturbances are commonly observed in dementia patients. As dementia and neurodegeneration can cause profound sleep disturbance, sleep disorders occurring just before dementia onset may be part of dementia’s natural history. However, several mechanisms point towards poor sleep as a dementia risk factor, with poor sleep linked to neuroinflammation, blood-brain barrier permeability, reduced synaptic plasticity and memory consolidation, hypoxic brain injury, and disrupted glymphatic clearance of neurotoxic brain waste. This talk will highlight Matthew Pase's recent work investigating poor sleep as a dementia risk factor.

About the presenter

Matthew Pase is Associate Professor at Monash University and Harvard University and an NHMRC Emerging Leadership Fellow (EL2). Matthew is Director of the Ageing and Neurodegeneration Theme at Monash’s School of Psychological Sciences and Lead of the Ageing Well Research Pillar at the Turner Institute for Brain and Mental Health. Matthew and his team aim to make dementia preventable for future generations by advancing our understanding of risk factors and early biomarkers. His research has contributed to a paradigm shift in thinking whereby managing vascular risk factors is now considered fundamental for preventing dementia. His research has reached a global audience of over 1.5 billion and has impacted current dementia prevention guidelines. In addition, Altmetrics have featured his research in the top 100 most impactful articles of all time out of over 17 million. Having obtained his Ph.D. in 2014, Matthew has already published over 115 papers and attracted over $30M in competitive funding from local and international sources. He leads several global initiatives and is Principal Investigator of the local Brain and Cognitive Health Cohort.

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